METTL3-M6A-CREB1 FORMS AN INTRINSIC REGULATORY AXIS IN MAINTAINING INKT CELL POOL AND FUNCTIONAL DIFFERENTIATION

Mettl3-m6A-Creb1 forms an intrinsic regulatory axis in maintaining iNKT cell pool and functional differentiation

Summary: N6-methyladenosine (m6A) methyltransferase Mettl3 is involved in conventional T cell immunity; however, its role in innate immune cells remains largely unknown.Here, we show that Mettl3 intrinsically regulates invariant natural killer T (iNKT) cell development and function in an m6A-dependent manner.Conditional ablation of Mettl3 in CD4+CD

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THE PROBABLE HAZARDS OF SUCROSE IN MAN

The effect of dietary sucrose on DNA formation in rat liver and kidney compared with that of starch was studied.Male, weanling rats were fed for 6 and 14 days on Baseball diets containing 68% 'sucrose or 68% starch, and liver and kidneys were examined for 1ilie amount and rate of formation of DNA; and also for content of fat, protein, and mois

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